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Several novel markers such as IGFBP-1, hs-CRP, adiponectin, ferritin, HbA1c, C3 complement, TNF alpha and sCD36 are now surfacing as surrogate markers of IR.[17] Other investigations for IR are fasting glucose and lipoprotein profile, hemoglobin A1c, body weight, blood pressure, and an alanine transferase test for evaluation of fatty liver.[6] ACANTHOSIS NIGRICANS AND CARDIOVASCULAR DISEASE Insulin resistance is thought to be a primary etiological factor in the development of cardiac dysfunction, higher prevalence being reported in nonischemic heart failure population

RTECs: renal tubular epithelial cells

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Orlistat blocks intestinal fat absorption leading to decreased liver fat content