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Pharmacophores of reported HDAC inhibitors have three main components: A zinc-binding group (ZBG) that chelates with the zinc ion in the active site of the protein, a cap group that interacts with residues on the proteins outer surface, and a linker that connects the cap group and ZBG 19

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Understanding what each peptide does, and why they work better together, is essential for evaluating whether this protocol is appropriate

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