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NRF2 also induces the expression of multidrug resistance proteins, superoxide dismutase, and heme oxygenase 1

During aging, the iron that accumulates in the retina, particularly in the choroid, retinal pigment epithelium (RPE), and photoreceptors [3,4,5], together with reduced intracellular antioxidant defenses, predisposes to oxidative stress-induced cell death

In the early stages of DKD, the majority of patients experience an insidious onset and few overt clinical symptoms and indicators, but they are prone to develop end-stage renal disease in the later stage, which is life-threatening

In the Y-maze barrier task, prenatal stress and THC reduced high-reward arm selection at low effort (10 cm) in males, whereas females showed reduced selection primarily after prenatal exposures to THC or THC/Stress