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There was also a cardioprotective effect of spermidine as demonstrated by Wang et al

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doi:10.1111/imr.13278 Gonzalez AL, Dungan MM, Smart CD, Madhur MS, Doran AC

Proc Natl Acad Sci U S A 107:1556570

The mechanism underlying the regulation of glucose homeostasis by E2 signaling is that the ER-expressing neurons in the ventrolateral subdivision of the ventromedial hypothalamic nucleus can sense glucose fluctuations throughout the body and regulate glucose homeostasis [194]