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The neuroprotective effects of the ketogenic diet are closely linked to its induction of metabolic remodeling and protein modification: by increasing -hydroxybutyrate levels, it specifically promotes -hydroxybutyrylation of key tricarboxylic acid (TCA) cycle enzymes (such as citrate synthase [CS] and succinate-CoA ligase subunit alpha [SUCLG1]), enhancing enzymatic activity and ATP production to improve neuronal energy metabolism

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Antifungals such as fluconazole and itraconazole inhibit the enzyme that is partially responsible for the metabolism of birth control pills, Dr

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10.1016/j.ejpb.2013.08.013 218 WillisL.HayesD.MansourH