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Funding Research reported in this publication was funded by the NHLBI Recipient Epidemiology and Donor Evaluation Study- III (REDS-III), which was supported by NHLBI contracts NHLBI HHSN2682011-00001I, -00002I, -00003I, - 00004I, 00005I, -00006I, -00007I, -00008I, and -00009I, as well as funds from the the National Institute of General and Medical Sciences (RM1GM131968 to ADA), NHLBI R01HL146442 and R01HL149714 (ADA), R01HL148151 (ADA, JCZ), the Boettcher Webb-Waring Investigator Award (ADA) and a Shared Instrument grant by the National Institute of Health (S10OD021641)

However, in cells co-expressing CTR and RAMP3, similar potency was observed for the analogues (Supplementary Fig

The mismatch between oxidized miRNAs and proteins might be involved in the initiation of apoptosis, that eventually leads to the cell death (Wang et al., 2015

Thats especially the case for those containing hydroquinone, which you can read more about here

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