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Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS

Retinol, aminophylline, capsaicin, and caffeine are among the most beneficial topical ingredients

Nevertheless, alterations in the PDK1/Mef2 pathway were not replicated in the FRDAkd-inducible mouse model of FRDA (Chandran et al., 2017)