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6 Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, United Kingdom

BCR/ABL The t(9,22) translocation that is pathognomonic of chronic myeloid leukaemia gives rise to the Philadelphia chromosome and to the chimaeric gene BCR / ABL , coding for a constitutively active tyrosine kinase that transduces mitogenic and anti-apoptotic signals to cancer cells