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Uncropped/unprocessed blot images (Fig

Finally, modification of the intestinal microbiota including the metabolism of certain components of red meat into harmful compounds (such as trimethylamine-N-oxide) seems to contribute to these negative effects [137,138]

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These inflammatory mediators further damage neurons and disrupt the BBB, allowing peripheral immune cells to infiltrate the CNS ( The interaction between excitotoxicity and neuroinflammation is critical for the development of long-term neurodegeneration