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Synthesized primarily in the human liver and kidneys from the essential amino acids lysine and methionine, L-carnitine relies on a complex cascade of cofactors for its production, including Vitamin C, Vitamin B6, niacin, and iron

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In contrast, apo C2 acts separately as a cofactor and activator of lipoprotein lipase so stimulates triacylglycerol hydrolysis and the clearance of triacylglycerol-rich lipoproteins