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Abstract To develop an LCMS/MS method for simultaneous quantification of mildronate and L-carnitine, and to investigate the pharmacokinetic profile of mildronate in rats, its effect on L-carnitine homeostasis, as well as the exposure characteristics, underlying mechanisms, and their associations with therapeutic efficacy and toxicity risks

White PD, Goldsmithb KA, Johnson AL, et al

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The LAI of each dog was compared to other echo measurements, including the left ventricular end-diastolic internal diameter normalized to body weight (LVIDDN), the left atrium to aorta ratio (LA/Ao), and the grade of mitral regurgitation (MR)