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Table 8.5: Example of fixed-schedule regimen Note: * In practice, a hybrid approach can be recommended with fixed schedule plus an additional diazepam dose (for example, 5 mg 6 to 12 hourly as needed, based on clinical observation or alcohol withdrawal scale scores)

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F (2, 31) = 8.5), ( c ) Measurement of the time spent in the open arms, during the Elevated Plus Maze test (n Young = 10 mice, n Aged = 10 mice, n Aged+GDF11 = 12 mice