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Active PGC-1 travels to the nucleus and upregulates Nuclear Respiratory Factors (NRF-1 and NRF-2), which stimulate the expression of Mitochondrial Transcription Factor A (TFAM)

In contrast, levels of Pseudofavonifractor , Alistipes , and Fusicatenibacter , all beneficial SCFA producers, were decreased compared to controls

(4900:) proprotein convertase subtilisin/kexin type 2 [Homo sapiens]

Real-world example: Post-game celebratory drinks after a strenuous sports match or a hard gym session are a realistic setting where meaningful fluid loss has already occurred before the first drink is even poured

AMPK activation enhances insulin sensitivity, increases glucose uptake in peripheral tissues, and decreases gluconeogenesis in the liver, according to BenhaddouAndaloussi et al