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Clinical data shows that dose escalation helps approximately 20-30% of patients who plateau, while the remaining majority see minimal additional benefit or worsening tolerability

Ethics statement The study received ethical approval from the Institutional Ethics Committee under the code GU-IEC(NIV)/02/Proj/015

Using the cognitive-behavioral techniques of flooding and systematic desensitization, the therapist and patient can work together to safely reintroduce situations that have become too anxiety-provoking for the patient

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Ferroptosis is involved in IBD, particularly intestinal epithelial cell death (5)