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Hyperaccumulators exhibit an unusually high uptake of HM at the root membrane level, which may be attributed to the presence of a high expression of an HM transporter in the plasma membrane (Skuza et al., 2022)

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Increased activity of the glycerol transporter, keratinocytes aquaporin-3 (AQP3), located in membrane microdomains, leads to increased glycerol transport to PLD2, resulting in the differentiation of keratinocytes derived from ICR CD-1 outbred mice, as evidenced by increased expression of epidermal differentiation markers, such as keratin 1, keratin 10, and loricrin [90]

In conditions like Long COVID, macrophages in the joint tissue release matrix metalloproteinases (MMPs), destructive enzymes that literally digest cartilage

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