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This is exemplified by variable responsiveness to therapeutics such as those targeting IL-23/IL-17 signalling, and other consistently observed differences in clinical course including progression and severity both within and between SpAs subtypes

Contrary to predictions based on experimental models, clinical studies have consistently reported reduced plasma TMAO levels in patients with IBD

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Similar to the in vitro results, LC dose-dependently inhibited HDAC activities in these cultured cancer cells as well (Fig