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10 More recently, several other agents have demonstrated clinical activity in HCC and have been incorporated into and adopted by major HCC guidelines, including lenvatinib 11 (multi-kinase inhibitor of VEGF, fibroblast growth factor, and PDGF pathways) in frontline and cabozantinib 12 (multi-kinase inhibitor of Met and VEGF pathways), regorafenib 13 (multi-kinase inhibitor of VEGF and angiopoietin receptor pathways), and ramucirumab 14 (anti-VEGF receptor 2 antibody) in the second-line setting