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These activities decrease oxidative damage markers, which frequently relates to increased motility and decreased DNA fragmentation scores

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however, it is originally colonized by the oropharynx and microaspirations from the gastrointestinal tract

Key target genes include those encoding components of the electron transport chain (ATP synthase subunits, cytochrome c), fatty acid oxidation enzymes (medium-chain acyl-CoA dehydrogenase, carnitine palmitoyltransferase 1), and transcription factors that amplify the metabolic signal (PGC-1 itself, NRF-1)