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User 13, at 280 pounds, specifically questioned whether his 0.25mg subcutaneous dose was insufficient given his body weight

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J Clin Endocrinol Metab 85 : 49084911 Choe YH et al

Therapeutic strategies discussed in this section are therefore organized around these high-priority resistance axes, emphasizing interventions with demonstrated or emerging clinical feasibility rather than theoretical vulnerability alone

Masterjohn: Well, I think its, I mean, I think we can, I think no one can dispute that theres a large proportion of people that have elevated fasting glucose