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21 Alpha-lipoic acid is a multifunctional compound in its ability to serve as a direct scavenger of free radical species and to also help in the regeneration of endogenous antioxidants such as glutathione 21 Supplementing with vitamin C has been shown to increase glutathione levels by exerting their antioxidant action first, thus sparing glutathione

Currently, cell monolayer model (e.g., Transwell model) was widely used to verify the BBB crossing and calculate the penetration efficiency

The duration and dose of treatment in these RCTs are not uniform

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This study has been carried out [198]