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Accordingly, the World Health Organization classifies G6PD-d based on the level of residual G6PD activity, with severe deficiency (Class I) causing chronic nonspherocytic hemolytic anemia and the least severe deficiency (Class IV) with little-to-no appreciable phenotype 8,11

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The species difference was recently explained by data indicating that, like EL-12, EFN- induces STAT4 activation in human cells but not in murine cells, and STAT4 has been shown to be required in EL-12 mediated T H I differentiation (Thierfelder et al

ATP levels were calculated based on an ATP standard curve