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Astrocytes in ALS show many signs of functional decline, for example they demonstrate abnormal Ca 2+ signalling, 573 impaired secretion of neuroprotective glial-derived neurotrophic factor, 574 as well as reduced lactate production

Puede haber disminucin de los reflejos tendinosos profundos, pero la hiperreflexia y la espasticidad sobrevienen cuando los cordones laterales estn involucrados

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Water and chemicals used for buffer preparation should be of high purity