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Celastrol, a bioactive triterpenoid, induces ferroptosis in HSCs by disrupting redox balance through inhibition of PRDXs and upregulation of HO-1, promoting lipid peroxidation and iron overload

It performs many roles, but primarily it acts as your most powerful antioxidant, combating free radicals and oxidative stress that can slow and eventually break down cellular function

10.1016/j.scispo.2018.02.006 172 ZhouQ.ZhuX.-J.LiJ.-H

386,387 The mitophagy activator urolithin A, which indirectly inhibits mTOR through the PI3K/AKT/mTOR pathway, has been shown to reduce cytosolic mtDNA-dependent activation of the cGAS/STING pathway and subsequent inflammation

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