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Aging myelin exhibits structural degeneration, such as balloon-like expansions and paranodal pilling, whereas OPCs lose differentiation potential and mature oligodendrocytes reduce metabolic support via downregulated MCT1 transporters and lipid synthesis [81]

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8 Toward a one health approach for cancer prevention in Africa 8.1 Policy integration: food safety, environmental health, and cancer control 8.1.1 Current fragmentation and its consequences Cancer prevention policy in African contexts typically operates through disease-specific vertical programs: cancer registries and treatment programs under ministries of health, food safety regulations under agriculture or commerce ministries, environmental health under environment ministries, and occupational health as a separate domain

Interestingly, genetic silencing of 6PGDH resulted in p53 accumulation and senescence in lung cancer cells