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[11] [12] [81] Tamoxifen binds to ER competitively (with respect to the endogenous agonist estrogen) in tumor cells and other tissue targets, producing a nuclear complex that decreases DNA synthesis and inhibits estrogen effects

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"The underreported symptoms are leads that came from patients themselves, unprompted, and clinicians could potentially pay attention to them." Lyle Ungar, Professor in CIS and a co-author of the study, says social media can offer insight into concerns patients may not always bring up during medical visits