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Furthermore, in vivo studies using the Balb/c nude mouse xenograft model with MHCC97-H cells have shown that treatment with varying doses of corilagin (10, 20, or 30 mg/kg) results in a significant reduction in tumor mass and volume, demonstrating a dose-dependent inhibition of tumor growth

2024;10 doi: 10.3389/fnut.2023.1281879

1 Introduction Colorectal cancer (CRC) remains a major global health burden, ranking as the third most frequently diagnosed cancer and the second leading cause of cancer-related mortality worldwide ( de novo anti-tumor immune response

10.4049/jimmunol.175.10.6531 49 XueL.SalimiM.PanseI.MjsbergJ

Research indicated that the tumor-associated bacteria in PDAC were moved from the gut to the pancreatic duct, and the microenvironment of this adenocarcinoma may enhance sensitivity to bacterial translocation (Leinwand and Miller, 2020)