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The disruption of normal iron homeostasis may contribute to the altered cellular iron distribution and subsequent regional accumulation observed in neurodegenerative disorders

Figure 4 Split Data-Set Results for Wild-Type MTHFR Enzyme For the sake of emphasis, significant correlates for between 63 and 65 variables in this part of the split data set (Table 8) were indexed for their level of significance using the formula Significance Index [SI] = [(1 P -value) 1000] with the following significance indices obtained: Caseness for schizophrenia or schizoaffective disorder relates to NA [SI = 100] and HPL/Creatinine [SI = 93], in a setting where catecholamines held significant correlates with the wild-type enzyme and where NA relates to SIR [SI = 100], GSI [SI = 93] and DOI [SI = 93] and NA relates to NA/MHMA [SI = 93]

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That debate needs more input

Tennakoon, J