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Microscopic examination of the permanent sections revealed a well-circumscribed, heavily pigmented neoplasm, arranged in nests and composed of epithelioid cells with round nuclei and prominent nucleoli, with admixed melanophages (Figure 3A)

They also nest occasionally on the ground in tall grass or amongst stones near water, or in cavity in bank or wall

The transdermal administration method not only avoids the inconvenience of injection but also provides a more stable blood drug concentration, especially suitable for patients with cardiovascular risks or those with contraindications to oral medications

Due to non-selective receptor activity, it also affects multiple physiological signaling systems

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