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[4] At the cellular level, free estradiol diffuses through cell membranes and binds to intracellular estrogen receptors and , which upon ligand activation dimerize and translocate to estrogen-response elements on nuclear DNA, modulating transcription of genes governing reproductive tract integrity, thermoregulation, bone metabolism, and vascular endothelial function

[6]Current Patent Assignee: PROTEOSTASIS THERAPEUTICS - WO2016/105477, 2016, A1 Location in patent: Page/Page column 0139

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The resulting spectral changes allowed us to monitor the balance between reduced (roGFP red ) and oxidized (roGFP ox ) forms of the sensor via ratiometric fluorescence microscopy 24

Microbiome-Derived Tryptophan metabolites and their Aryl hydrocarbon Receptor-Dependent agonist and antagonist activities