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doi: 10.1097/01.ogx.0000238674.98471.bb

Although the mechanisms by which these reagents modulate GPx1 expression are not clear, it has been shown that GPx1 can be upregulated by activation of the peroxisome proliferator-activated receptor--coactivator-1a (PGC1) pathway, possibly via the subsequent activation of Nrf2 [161]

K., Ramalingam S

A pH of 7.4 was used to simulate neutral physiological conditions, while a pH of 5.6 was selected to mimic the acidic environment of endosomes in tumor cells