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Objective and design: In the presented study we compared the effect of stable peptide BPC 157 and methylprednisolone on early functional recovery after Achilles tendon to bone transection in a rat model before collagen healing started

This phenomenon, known as metabolic endotoxemia, has been linked to: Chronic inflammation Insulin resistance Obesity Metabolic syndrome In animal studies, even modest increases in circulating endotoxins have been shown to trigger inflammatory responses that interfere with metabolic regulation

Recently, accumulating evidence demonstrated that dysregulated oxygen sensing in the diseased kidney is the underlying mechanism resulting in anemia (Li et al., 2022

Animal and cell-culture studies point to three overlapping pathways: promotion of angiogenesis (new blood-vessel formation, linked to VEGF), support for collagen and tendon repair, and anti-inflammatory effects

Oser MG, Jnne PA