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[3] PubMed

The excessive infiltration of SMs into synovia causes articular immune dysfunction, accelerates the progression of synovitis, and leads to osteoclast activation and ultimate bone erosion and joint destruction 7,8

Maiuri et al., 2007)

Erastin inhibits system Xc to lower GSH, reverses the Warburg effect, and thus primes mitochondria to amplify copper-mediated cuproptosis, culminating in irreversible mitochondrial damage