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M.ZerresK.et al (2008)

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That is their primary therapeutic effect for weight management

Maximum Responder Rate (20%+ Loss) CagriSema 60% of CagriSema patients achieved at least 20% weight loss in REDEFINE 1, a higher responder rate than tirzepatide's across-trial data, though cross-trial comparison has limitations

This deleterious process is initiated by the activation of CNS-resident microglia, which release an array of cytokines and chemokines, including C-C motif chemokine ligand 2 (CCL2) and C-X-C motif chemokine ligand 10 (CXCL10), that not only amplify local inflammatory responses but, more critically, alter BBB permeability through disruption of tight junction integrity (53, 54)