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Proc Natl Acad Sci USA (1987) 84:30048

4.0 mL + 0.2 mL NaOH, 2 mol/L): 0.050 Melting range: +189 to +200C Specific rotation: -16.5 to -21.4 Purity (enzymatically and iodometric): 98% Purity (iodometrically): 98% Loss on drying (+105C, 2 hours): 1% Glutathione, oxidized form (enzymatically): 1.5% Fe (bathophenanthroline): 5 ppm Heavy metals (as Pb, AAS): 5 ppm Methanol (GC): 50 ppm Aceton (GC): 50 ppm Ethanol (GC): 0.1% Stability: At +2 to +8C within specification range for 24 months

In the same study, higher spermidine levels were associated with good water maze performances and decreased anxiety, whereas spermine had the opposite effect, suggesting differential roles for spermidine and spermine in behavioural outcome

Because of these benefits, glutathione has become popular as a supplement, especially in the realm of skin brightening and anti-aging

Repeated measures one-way ANOVA and Tukeys honest significant difference tests were used to compare groups