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doi: 10.1089/ars.2007.1716 63 HlouschekJRitterVWirsdrferFKleinDJendrossekVMatschkeJ

Oxidized lipoprotein lipids and atherosclerosis

Lifespan extension in animal studies Rodent studies (most extensive data): Mice lifespan increased 20-42% with Epithalon Rats showed 12-25% lifespan extension Both maximum lifespan and median lifespan increased Healthspan (healthy years) improved even more Similar to effects seen with caloric restriction but without dietary limitation Study examples: Mechanisms of lifespan extension: Telomere preservation preventing cellular senescence Reduced oxidative damage to tissues Improved immune function preventing infections Better hormone regulation (pineal, reproductive) Reduced age-related diseases (cancer, cardiovascular) Human lifespan effects (theoretical): No completed human lifespan studies (require decades) If similar extension: 20% of 80-year lifespan = 16 additional years More realistically: Healthspan improvement more achievable than lifespan Quality of life in later years potentially enhanced Similar goals as other longevity interventions Limitations of animal data: Rodents humans (metabolism, telomere biology differ) Controlled lab conditions vs real-world human life Optimal dosing in humans unknown Long-term safety in humans not established Need rigorous human trials for validation Compare to other longevity approaches like growth hormone peptides at SeekPeptides

The Type IV Phosphodiesterase Inhibitor Rolipram Induces Expression of the Cell Cycle Inhibitors P21(Cip1) and P27(Kip1), Resulting in Growth Inhibition, Increased Differentiation, and Subsequent Apoptosis of Malignant A-172 Glioma Cells

3.1.2 PKM2: driven metabolic rewiring Pyruvate kinase is the rate-limiting enzyme that catalyzes the conversion of phosphoenolpyruvate (PEP) to pyruvate, serves as a critical metabolic and immunological node in T cell fate determination