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Both ceramide and sphingosine are vital regulators of stress responses, possessing the capability to inhibit cellular proliferation and mediate apoptosis, growth arrest, senescence, and differentiation (Pralhada Rao et al., 2013)

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The authors concluded that ,acrolein is not just a pollutant but also a lipid peroxidation product that could be ubiquitously generated in biological systems [33]

R 4 is (1) hydrogen, (2) (C 1-3 )alkyl, or R 3 and R 4 , together with the nitrogen atom to which they are attached, combine to form a mono- or bicyclic heterocyclyl ring containing 1 N and optionally containing 1 additional heteroatoms independently selected from N, O and S, wherein the heterocyclyl ring is unsubstituted or substituted by 1, 2, or 3 R 11