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In certain condition such as hepatic cirrhosis the ability to convert methionine to SAM is disturbed

After dividing participants into two groups by sex, we found that only males showed a decrease of PRESS GSH levels in the ACC with age and a significant group difference in the relationship between GSH levels and age

Cytosolic glutamate is critical for GSH synthesis, which in turn functions as reducing substrate for GPX4, an essential enzyme to protect the cell against oxidative damage (Figure 1A)

Moreover, some of them carry out enzyme activators functions and enter the genesis of hormones and vitamins

(London England) 38 (1), 12 (2018)