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Among the various applications for CPP-aided transepithelial transport, antidiabetic peptides, such as insulin, and exendin-4, were studied for its systemic and brain delivery via the nasal administration route (Figure 3)

The peptide reaches peak plasma concentration while endogenous nicotinamide levels are at their circadian low point, which occurs in the early morning hours before food intake

Subcutaneous injections : A preferred method for musculoskeletal or soft tissues

The rationale is that exercise increases blood flow to the target area, which could theoretically improve the delivery and uptake of the peptide