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During critical illness, muscle concentrations of GSH decrease and a change in the redox status occurs, indicative of an elevated GSSG [24]

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During this process, pre-luminal ( SULT1E1 ) and pre-glandular ( OPRK1 , SUFU , CBR3 , HPRT1 ) cells differentiate into mature luminal ( WNT7A , LGR5 , PTGS1 ) and glandular ( ITGA1 , HPGD , SLC47A1 ) cells, respectively [25]