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The cool temperature provides a mild vasoconstriction effect when applied reducing morning puffiness more effectively than room-temperature application

Furthermore, the combined use of (-)-Vestitol and Salviolone introduces the possibility of interactions beyond the observed synergistic effects for AD

It is worth being precise: these are proposed and studied mechanisms, not settled clinical facts

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Direct application of ointment is the most commonly used form of administration at present, but only a few drugs can effectively penetrate into the dermal layer with therapeutic concentrations through this route [29]