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Cascade POD-CAT mimics Mannose-coated superparamagnetic iron oxide nanoparticles (mSPIONs) exhibit POD and CAT-mimetic activities, facilitating ROS removal via cascade reactions

288-290 Given the absence of untreated controls, randomized designs, and/or placebo control groups, the studies cannot be interpreted because of the inability to account for change over time in disease state independent of treatment

Journal of Biotechnology 188:7280

To examine the role of ASGPR in efficacy of various liposome formulations, wildtype and ASGPR knockout mice were administered MC3 liposomes containing the AD-1661 siRNA composition, at 3, 1, and 0.3 mg/kg as described in Example 1