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Only Manganese superoxide dismutase (MnSOD), the main mitochondrial neutralizer of ROS, has been shown to be crucial for the survival of aerobic life (26)

Unlike other metals like iron, the mechanisms of copper-induced cell death are not well understood

Transfection of GES-1 cells with miRNA-143, miRNA-152, and miRNA-181 mimics significantly decreased mature miRNA expression accompanied by xCT mRNA, and protein expression was significantly suppressed (Figures 4A,B)

Interestingly, Rawls et al (2004) showed that genes involved in cholesterol metabolism and trafficking as well as in bile acid biosynthesis could be modulated by the microbiota in both mice and zebrafish