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Masson's trichrome staining of cavernosal tissues demonstrated a significant change in the collagen-to-smooth muscle ratio in HHcy-associated ED cases compared to non-ED and naturally aging ED patients, providing structural evidence for Hcy-mediated corpora cavernosa vascular sinus remodeling (Figure 1G)

Guzzi G, Grandi M, Cattaneo C, Calza S, Minoia C, Ronchi A, Gatti A, Severi G (2006) Dental amalgam and mercury levels in autopsy tissues: Food for thought

Therefore, the metabolic milieu directs T cell lineage commitment through opposing lipid-sensing pathways, wherein SCFA-mediated immunomodulation counterbalances pro-inflammatory fatty acid signaling to maintain mucosal immune equilibrium and restrain pathological inflammation

and (7) developing an international consensus framework to guide experimental design, endpoint selection, and data transparency