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Berberine has been reported to act as a naturally occurring MET inhibitor that synergizes with ositinib to overcome acquired resistance to ositinib caused by MET amplification [227]

These classifications are not based on the severity of disease, although certain phenotypes may correlate with increased risk for more severe disease

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Oxidative stress was also reported in ASD, and it is one of the factors that impair ADAM10 function, which might contribute to the pathophysiology of cognitive impairment in ASD patients

These findings have significant implications for the clinical evaluation and rehabilitation strategies of patients with PD, suggesting that interventions should focus on optimizing the temporal coordination of muscle synergies and preparatory postural strategies in patients with PD