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doi: 10.1073/pnas.1703998114

ACKNOWLEGEMENTS This work was supported in part by National Institutes of Health grants HL116263 and HL127173

Reina-Gutierrez S

En modelos animales preclnicos, dado su carcter de molcula pequea oral-activa, los diseos han contemplado dosificacin por va oral o intraperitoneal segn el protocolo aprobado por el comit de tica institucional, con esquemas de administracin diaria y ventanas de tratamiento que abarcan varias semanas para observar efectos sobre composicin corporal