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Conclusion Cysteine metabolism plays a crucial role in the pathogenesis of AA, impacting diverse biological pathways ranging from oxidative stress and disturbances in keratin functionality to autophagy, immunity and ferroptosis

On the other hand, these subcellular responses also affect autophagy, e.g

Interestingly, SP3CHO is slightly more potent and shows a more pronounced hook effect (a phenomenon typically observed with PROTACs) in the absence of FCS (Fig

Its compact backbone and lack of extensive modifications distinguish it from stabilized peptide analogs, enabling its use as a model compound for studying peptide signaling, receptor interactions, and metabolic degradation pathways