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Notably, patients with lower LIPT1 expression exhibited better overall survival, suggesting that reduced LIPT1-mediated mitochondrial lipoylation may enhance susceptibility to copper-induced stress and suppress tumor progression

345,346,347 Altogether, obesity and IR play pivotal role in women with PCOS and subsequent metabolic complications, and targeting these areas may become an important therapeutic approach for effectively reducing incidence of this pathology

These findings highlight the mucoadhesive nature of chitosan as a key factor in prolonging the residence time of nanoparticles at the absorption site, thereby facilitating improved drug permeation and absorption

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10.1016/0031-9422(91)84102-X 44 El-ZahabyH