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The culture media were replaced every 23 days with fresh medium containing HEM, HeA, HeC, or HeS

10.1016/j.freeradbiomed.2019.08.001 Free Radic

Dopaminergic neuronal function is typically assessed by performing a dopamine transporter scan (DAT scan), which shows reduced and asymmetric binding in the striatum of patients with idiopathic PD, whereas in individuals with Mn-induced parkinsonism, the DAT scan is mostly normal or reveals a slight decrease in dopamine uptake [56]