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Intracellular ROS and/or RNS induced the production of protein hypersulfonic acid (P-SOH) or glutathione hypersulfonic acid (GSOH) intermediates, leading to modification

~2-6 hours (estimated, polypeptide complex) Varies by component (~1-6 hours) ~0.5-2 hours (estimated, tetrapeptide) ~0.5-2 hours (estimated, ultrashort peptide) ~3-4 hours (estimated, based on peptide clearance kinetics) 2.5-3.5 hours (subcutaneous/IV) ~30-45 min IV plasma (functional effects persist 2-4 hours via SubQ absorption) ~2-4 hours (estimated) ~3 min (IV), central effects last 2-4 hours (intranasal) ~2-4 hours (estimated, D-retro-inverso form may extend effective duration) ~2-4 hours (estimated) ~2-4 hours (estimated from in vitro decay

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One unadjusted model (model 1) combined with two adjusted models (model 2 and model 3) were established

In vitro effects of hydroxybenzaldehydes from Gastrodia elata and their analogues on GABAergic neurotransmission, and a structure-activity correlation