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SYN-treated BV2 cells demonstrated increased expression of TLR2 and TLR3 with a down regulation of TLR4 and TLR7 compared to buffer-treated BV2s

27,28 On the other hand, in a recent in vitro study conducted by Binch and colleagues, 29 ADSCs cultured in an IDD-mimicking media (5% O 2 and preconditioning with a proinflammatory stimulus) showed significantly higher levels of pain-associated neurotrophic and angiogenic factors in ADSC cultures compared to BM-MSCs, which may in turn promote neurovascular invasion of the degenerated IVD and thus contribute to discogenic LBP

Zhou H, Yang C, Li J, He Y, Huang Y, Qin R, et al

An mRNA Vaccine Against SARSCoV-2 Preliminary Report